Inborn analgesia
Pain is a sensory modality present in all complex organisms and used to detect potential and real tissue damage. Although it is an unpleasant sensory and emotional experience, it substantially affects our behaviour, providing a survival advantage. Normally, pain is detected by a complex system of mechanical and chemical sensors called nociceptors, which then send information through spinal interneuronal pathways to the brain. However, in a number of rare conditions, components of the pain-signalling pathway may be impaired or fail to develop. One such condition is congenital insensitivity to pain (CIP), where individuals are unable to perceive pain from birth.There are two common forms of CIP. First, loss-of-function mutation in the SCN9A renders nociceptors unable to respond to any noxious stimulus. Second, loss-of-function mutation in the NTRK1 leads to a failure of nociceptors to develop. Recently, a new form of CIP has been described, caused by mutations in an epigenetic regulator PRDM12. The phenotype of these patients was briefly annotated in the initial study
Other
Inborn analgesia also known as congenital insensitivity to pain is a condition, present from birth, that inhibits the ability to perceive physical pain. Affected individuals are unable to feel pain in any part of their body. Over time, this lack of pain awareness can lead to an accumulation of injuries and health issues that may affect life expectancy. Here in this report the way of taking care of those people will be discussed
