It Could Be Worst Than That ! Sarcoidosis

Sarcoidosis is a multisystem disease of unknown etiology. • The diagnostic histopathologic feature is the presence of non-caseating granulomas in various tissues. • Immunologic abnormalities include high levels of CD4+ TH1 cells in the lung that secrete cytokines such as IFN-γ. • Clinical manifestations include lymph node enlargement, eye involvement, skin lesions and visceral involvement (liver,skin,bone marrow)