Gender Difference in Antidiuretic Response To Furosemide

Abstract

Urine output is the urine 24-hour volume test that measures the amount of urine produced in a day in both male and female. The possibility of gender differences in the relationship between dose and efficacy of drugs has historically been limited. The aim of this study was to evaluate the influence of gender on the pharmacodynamics of Furosemide (FUR) in adults. We measured the diuretic response to oral Furosemide. In 6 females, normal volunteers 367.2± 104.9 range from 216.0 to 518.4 ml and the mean of urine output among male after 6 hour was 468.0± 114.02 range from 302.4 to 604.8ml. After fasting overnight, each received a single doses of Furosemide 40 mg. The end result shows was there were no statistical significant different between both genders and urine output (p > 0.05) which is (P=0.142) .