| dc.description.abstract | Gender has been shown to make a difference in the nature of the drug and its response to treatment. Diuretic responses to oral and intravenous furosemide were measured in 6 male and 6 female healthy subjects. After an overnight fast, each subject received a single dose or no treatment of each diuretic over four days. Total urine output was collected over the next 24 hours for volume measurement and sodium and potassium concentration measurements. There were no statistically significant differences between male and female subjects in terms of urine output, sodium and potassium excretion rates between treatments. However, when the natriuretic response was adjusted for the intravenous furosemide dose of mg / kg, male subjects showed higher peak sodium excretion rates than female subjects. The results of this study show that there is a gender difference in the response of sodium diuretics to diuretics. Further studies are needed to determine whether this gender difference is caused by differences in drug metabolism, pharmacokinetics, or endogenous diuretic responses at the site of action.1
Aim Possibility of gender differences in relationships It was historic between dose and efficacy exclusive. The purpose of this study is Gender effect of furosemide (FUR ) on pharmacodynamics in adult 3 | en_US |
