Febrile seizures are the most common convulsive disorder in children under 5 years old. Among these children, some develop recurrent febrile seizures. The syndrome of febrile seizures is defined as seizures associated ...

Different cancers affect millions of people around the world and is considered one of humanity's greatest challenges, traditionally cancer is tackled by therapeutic methods such as radiation or surgery, chemotherapy as ...

Antimicrobial resistance (AMR) occurs when microbes become resistant to the antibiotics that are designed to cure them. Genetic interactions or epistasis of AMR mutations play an important role in determining the ...

Muscular dystrophies are a group of genetic muscle disorders that cause progressive muscle weakness and degeneration. Within this group, Duchenne muscular dystrophy (DMD) is the most common and one of the most severe. ...

Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies implicate multiple pathways through which vitamin D may affect cardiovascular function and influence risk for heart failure. ...

Alzheimer disease (AD) is the most frequent cause of dementia in elderly. It leads to progressive cognitive decline due to accumulation of two proteins (β-amyloid peptide (Aβ) and Tau) in the forms of senile plaques and ...

Immune checkpoint blockade has used as a treatment of patients with advanced melanoma and many other cancers. Blockade of inhibitory receptors, cytotoxic Tlymphocyte antigen 4 (CTLA-4) and programmed cell death receptor ...

Myasthenia gravis (MG) is an autoimmune disease caused by complement-fixing antibodies against acetylcholine receptors (AChR). Cholinesterase inhibitors, Glucocorticoid , which is currently recommended as a first-line ...

Tay-Sachs disease is an autosomal recessive disease characterized by progressive neurologic degeneration, fatal in early childhood. In the Ashkenazi Jewish population the disease incidence is about 1 in every 3,500 ...

Multiple Sclerosis (MS) is a neurodegenerative disease of the central nervous system, in which B-cells play an important role in its pathogenesis. However, Ocrelizumab (OCR) is a humanized anti-CD20 monoclonal antibody ...

Immunotherapy is revolutionizing the management of multiple solid tumors, and early data have revealed the clinical activity of PD-1/PD-L1 antagonists in small numbers of metastatic breast cancer patients. Clinical ...

Microarrays are a technology to which thousand nucleic acids are attached to a surface that's used to estimate the relative concentration of nucleic acid sequences in a mixture by hybridization and hybridization event ...

Diabetic foot ulcer is a principal diabetic complication. It has been shown that diabetic patients have decreased growth factor concentrations in their tissues, particularly epidermal growth factor. Growth factor shortage ...

Asthma and hypertension are common chronic diseases , each with attendant morbidity, mortality, and economic effects.The presence of hypertension with asthma creates an additional health burden; hypertension is the world’s ...

The fragile X syndrome, an X-linked dominant disorder with reduced penetrance, is one of the most common forms of inherited mental retardation. The cognitive, behavioral, and physical phenotype varies by sex, with males ...

Vaccines aim to protect individuals from infectious diseases. The importance of vaccine such as prevention of hospital infections, cost efficiency, and overall protection to infections. The disadvantage of administration ...

Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by impaired social communication and restricted and repetitive behaviors (RRBs). Over the past decade, neuroimaging studies ...

Age-related macular degeneration (AMD) is one of the leading causes of irreversible central vision loss in elderly individuals, further affecting their ability to do everyday tasks, from reading to even recognizing faces, ...

This report evaluated the efficacy and safety of istradefylline in Parkinson’s disease patients with wearing-off symptoms and dyskinesia. Parkinson’s disease (PD) is the second-most common neurodegenerative disorder after ...

Objective to report 2 cases of Guillian barre syndrome with different manifestations Guillain Barre Syndrome consists of a group of neuropathic conditions characterized by progressive weakness and diminished or absent ...