Progression of symptoms in Huntington Disease (HD)

Abstract

Background : disease previously described as genetically programmed cell death in human CNS is known now days as Huntington’s disease (HD) previously as (Huntington chorea) ,basically this report explains the progression of symptoms in the early and middle stages of Huntington disease , Material and methods : in this paper the progression is clarified through a survey of question answered by first degree relatives to the participants , the survey mentioned below holds 19 symptoms of (HD), the goal of this report is to describe or portray the progression of symptoms in the early and middle stages of Huntington disease (HD), Result : the symptoms were classified into 6 groups which are (initial , early ,early-middle, middle , middle-late and late) varying in the time of onset from 1 year to 2-5 years then 6-10 and finally up to 10 years , Discussion : patients who suffered of HD for more than 10 years adequately lower the sample size; therefore, the answers for the category of after more than 10 years were excluded in the analysis, . after the analysis of the answers of the affected questioner (AQ) the larger slope estimates indicate an early onset, while the symptoms with smaller slope indicate symptoms that happen later in disease progression. Conclusion: in conclusion the early and middle symptoms of Huntington are unclear unlike the middle-late and late stages , also describing the initial symptoms helps better the development of the therapeutic agents .