Show simple item record

Advanced Treatment of Amyotrophic Lateral Sclerosis (ALS)

dc.contributor.authorJamal Bennour, Mohammed
dc.date.accessioned2020-09-28T10:30:09Z
dc.date.available2020-09-28T10:30:09Z
dc.date.issued2019-11-21
dc.identifier.urihttp://repository.limu.edu.ly/handle/123456789/2024
dc.descriptionAmyotrophic lateral sclerosis (ALS) is the most common form of the neurodegeneration , is progressive and fatal neuromuscular disease , the disease characterized by the degeneration of motor neurons in the brain and spinal cord , when the motor neurons die , the ability of the brain to control muscle movement lost, the people loss the ability to speak , move , eat , breath . Approximately half of (ALS) patients die within 3-5 years of symptoms onset , the (ALS) usually strikes people between the age 40-70 , the disease is discovered by French doctor named ( jean-martin charcot) , “ Amyotrophy “ refers to the atrophy of the muscle fibers , which are denervated as their corresponding anterior horn cell degenerate , “ Lateral sclerosis” refers to hardening of the anterior and lateral corticospinal tracts as motor neurons in these areas degenerate and are replaced by gliosis .en_US
dc.description.abstractBackground: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disease that affects approximately 5 of every 100,000 individuals, Approximately half of ALS patients die within 30 mo of symptom onset and the majority do not survive beyond 5 years, Currently, riluzole and edaravone are the only United States Food and Drug Administration (FDA)–approved treatment options Methods: Outcome (the change in ALS Functional Rating Scale–Revised, ALSFRSR, from baseline) was projected for placebo patients through 48 weeks and compared with 48-week edaravone or 24-week edaravone after switching from placebo. Results: A total of 123 patients received open-label treatment (65 edaravoneedaravone; 58 placebo-edaravone). The projected ALSFRS-R decline for placebo from baseline through week 48 was greater than for 48-week edaravone (P < .0001). For patients switching from placebo to edaravone, ALSFRS-R slope approached that of continued edaravone for 48 weeks. ALSFRS-R decline did not differ between actual and projected edaravone through week 48. Conclusions: Compared with placebo, these analyses suggest that edaravone is beneficial in ALS patients even after 6 mo of receiving placebo, and efficacy is maintained for up to 1 year.en_US
dc.language.isoenen_US
dc.publisherfaculty of Basic Medical Science - Libyan International Medical Universityen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.titleAdvanced Treatment of Amyotrophic Lateral Sclerosis (ALS)en_US
dc.typeOtheren_US


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States