dc.description | Breast cancer is a type of cancer that starts in the breast, when cells begin to grow out
of control, and Breast cancer cells usually form a tumor that can often be seen on an
x-ray or felt as a lump. Breast cancer occurs almost entirely in women, but men can
get breast cancer, too. TNBC (Triple Negative Breast Cancer) is cancer that tests
negative for three hormones receptors, estrogen receptors, progesterone receptors, and
have little or no HER2 protein expression.
(5,6)
The lacking of expression of estrogen receptor (ER), progesterone receptor (PR) and
human epidermal growth factor receptor (HER2) describe the TNBC ( Triple
Negative Breast Cancer ) which is a subgroup of tumors(1)
, However, TNBC ( Triple
Negative Breast Cancer ) are a collection of different breast cancers that are still
poorly characterized at the molecular level, and lack definitive prognostic markers
and selective targets of therapy(2)
. Although its incidence is still high, the overall
mortality due to breast cancer has decreased, in addition, it accounts for about 15% of
all breast cancers, and it occurs more in younger women than the older ones and it
occurs more frequently in individuals with a germline BRCA1 mutation.(3) | en_US |