dc.contributor.author | AbbAs Njem, Salwan | |
dc.date.accessioned | 2020-09-28T10:27:50Z | |
dc.date.available | 2020-09-28T10:27:50Z | |
dc.date.issued | 2019-03-11 | |
dc.identifier.uri | http://repository.limu.edu.ly/handle/123456789/2014 | |
dc.description | Antibiotics are paramount strong substance prevent the growth of the bacteria that
causes infections and can cure infections when used in right way They either hinder
bacteria from reproducing or destroy them. Antibiotics cannot treat viral infections,
such as cold, flu, and most coughs. The main antibiotic was penicillin. Penicillin-based
antibiotics, such as amoxicillin, ampicillin and penicillin G, are yet available to treat a
assortment of infections and have been around for quite a while. Lot types of modern
antibiotics are obtainable, and they are usually only available with a prescription in
generality countries. Topical antibiotics are approachable in over-the-counter (OTC)
creams and ointments. Excessive intake of antibiotics has a high-risk including
resistance acquired by bacteria damage to the liver and also cannot be forgotten
nephrotoxicity. | en_US |
dc.description.abstract | Typically the nephrotoxic beta-lactam antibiotics trigger acute proximal tubular
necrosis. Significant renal toxicity, which has been rare with the penicillin’s and
uncommon with the cephalosporins, is a greater risk with the penems. Mechanisms of
injury include transport into the tubular cell, mainly through the antiluminal organic
anion secretory carrier, concentrative uptake through a secretory carrier, based on the
consistent correlation between transport and toxicity . (II) Molecular mechanisms: (a)
production of a highly reactive acylating metabolite by a cytochrome P-450 dependent
mixed-function oxidase; it is the only beta-lactam shown to cause significant oxidative
injury; very low limited ability to harm the mitochondrial carriers with regard to
pyruvate and the short-chain fatty anions. | en_US |
dc.language.iso | en | en_US |
dc.publisher | faculty of Basic Medical Science - Libyan International Medical University | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.title | Relationship between Nephrotoxic and Antibiotics | en_US |
dc.type | Other | en_US |