Guillain Barre Syndrome.
Guillian Barre Syndrome GBS is rapidly progressive disorder of Muscle weakness sometimes progressing to complete paralysis , this Syndrome effect approximately only one or two people each year in every 100,000 population . Although its precise cause is unknown . About half the patient have a gastrointestinal or respiratory infection a few days before the onset , there is strong evidence that the immune response to the infection produces autoimmune response which damage the nerve causing weakness and loss of (1) sensation
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Objective to report 2 cases of Guillian barre syndrome with different manifestations Guillain Barre Syndrome consists of a group of neuropathic conditions characterized by progressive weakness and diminished or absent mitotic reflexes. The estimated annual incidence in the United States is 1.65 to 1.79 per 100,000 persons. Guillain Barre syndrome is believed to result from an aberrant immune response that attacks nerve tissue. This response may be triggered by surgery, immunizations, or infections. The most common form of the disease, acute inflammatory demyelinating polyradiculoneuropathy, presents as progressive motor weakness, usually beginning in the legs and advancing proximally. Symptoms typically peak within four weeks, then plateau before resolving. More than one-half of patients experience severe pain, and about two-thirds have autonomic symptoms, such as cardiac arrhythmias, blood pressure instability, or urinary retention. Advancing symptoms may compromise respiration and vital functions.
